該基因編碼的蛋白質(zhì)是atp結(jié)合盒（abc）轉(zhuǎn)運(yùn)蛋白超家族的成員。abc蛋白通過細(xì)胞外和細(xì)胞內(nèi)的膜運(yùn)輸各種分子。abc基因分為七個(gè)不同的亞家族（abc1，mdr/tap，mrp，ald，oabp，gcn20，white）。這種全轉(zhuǎn)運(yùn)蛋白是mrp亞家族的一員，參與多藥耐藥。該蛋白作為一種多特異性有機(jī)陰離子轉(zhuǎn)運(yùn)蛋白，以氧化戊二酮、半胱氨酸白三烯和活化的黃曲霉毒素b1為底物。這種蛋白質(zhì)還運(yùn)輸葡萄糖醛酸和類固醇激素和膽鹽的硫酸鹽結(jié)合物。該基因的選擇性剪接變體已經(jīng)被描述，但其全長(zhǎng)性質(zhì)未知。[由RefSeq提供，2012年4月]
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]