小鼠氣溶膠肺部給藥（氣管內給藥）套裝 / 大小鼠肺部給藥裝置 (Liquid Aerosol Devices, MicroSprayer? Aerosolizers) 輸送氣溶膠提供了更好的方案，更方便、更安全、更快捷。 套裝主要包括氣溶膠霧化噴射頭，高壓注射器組成。

• 定量 QUANTIFIABLE：將定量的氣溶膠給到動物肺部

• 定時 TIMED：可以在一個或多個時間點進行給藥

• 有效 EFFECTIVE：氣溶膠的吸收效果好，給藥快速，效率高，操作方便

• 方便 CONVENIENCE：維護簡單，操作方便

小鼠肺部干粉給藥套裝，歡迎來電咨詢：
 

n  產品特點

·  快速 、 精確的直接肺 部給藥 ——氣溶膠 無 浪費

·  純機械 動力，無外部空氣進入

·  不需加熱、 推進劑、超聲波或壓縮空氣 等，對藥物物影響

·  手持式設計的獨特專利，使用非常方便

·  噴射頭頂端圓滑的設計，保證安全、溫和的插入氣管內

·  可高溫高壓消毒滅菌，可重復使用

·  比其它霧化器和吸入設備提供更高濃度發(fā)藥物體積或劑量

·  比傳統(tǒng)滴注法給藥提供更均勻的藥物分布

n  使用方法

參考文獻：

1. Li, Cheng et al. “Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody.” Cell vol. 185,8 (2022): 1389-1401.e18. doi:10.1016/j.cell.2022.03.009

2. Peng, Boya et al. “Robust delivery of RIG-I agonists using extracellular vesicles for anti-cancer immunotherapy.” Journal of extracellular vesicles vol. 11,4 (2022): e12187. doi:10.1002/jev2.12187

3. Wu, Lan et al. “Poly(lactide-co-glycolide) Nanoparticles Mediate Sustained Gene Silencing and Improved Biocompatibility of siRNA Delivery Systems in Mouse Lungs after Pulmonary Administration.” ACS applied materials & interfaces vol. 13,3 (2021): 3722-3737. doi:10.1021/acsami.0c21259

4. Tian, Xidong et al. “Pulmonary Delivery of Reactive Oxygen Species/Glutathione-Responsive Paclitaxel Dimeric Nanoparticles Improved Therapeutic Indices against Metastatic Lung Cancer.” ACS applied materials & interfaces vol. 13,48 (2021): 56858-56872. doi:10.1021/acsami.1c16351

5. Gu, Peiyu et al. “Protective function of interleukin-22 in pulmonary fibrosis.” Clinical and translational medicine vol. 11,8 (2021): e509. doi:10.1002/ctm2.509

6. Su, Ruonan et al. “Venetoclax nanomedicine alleviates acute lung injury via increasing neutrophil apoptosis.” Biomaterials science vol. 9,13 (2021): 4746-4754. doi:10.1039/d1bm00481f

7. Yang, Huilin et al. “Triptolide dose-dependently improves LPS-induced alveolar hypercoagulation and fibrinolysis inhibition through NF-κB inactivation in ARDS mice.” Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 139 (2021): 111569. doi:10.1016/j.biopha.2021.111569

8. Wu, Yanqi et al. “SN50 attenuates alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome mice through inhibiting NF-κB p65 translocation.” Respiratory research vol. 21,1 130. 27 May. 2020, doi:10.1186/s12931-020-01372-6

9. Han, Meishan et al. “Engineering of Stimulus-Responsive Pirfenidone Liposomes for Pulmonary Delivery During Treatment of Idiopathic Pulmonary Fibrosis.” Frontiers in pharmacology vol. 13 882678. 25 Apr. 2022, doi:10.3389/fphar.2022.882678

10. Wu, Lan et al. “Quantitative comparison of three widely-used pulmonary administration methods in vivo with radiolabeled inhalable nanoparticles.” European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V vol. 152 (2020): 108-115. doi:10.1016/j.ejpb.2020.05.004

11. Peng, Jianqing et al. “Carboxymethyl Chitosan Modified Oxymatrine Liposomes for the Alleviation of Emphysema in Mice via Pulmonary Administration.” Molecules (Basel, Switzerland) vol. 27,11 3610. 4 Jun. 2022, doi:10.3390/molecules27113610

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注：該產品未在中華人民共和國食品藥品監(jiān)督管理部門申請醫(yī)療器械注冊和備案，不可用于臨床診斷或治療等相關用途。